DeFAI, AI Agents, and DeSci Have Been Obliterated in 2025

Decentralized Finance AI (DeFAI), AI Agents, and Decentralized Science (DeSci) were hailed as the future of crypto last year. Now, they are the three worst-performing crypto sectors of 2025. Dexu data indicates that DeFAI, a crypto category that combines Decentralized Finance (DeFi) with AI to provide unique crypto experiences in trading, risk management, and yield optimization, is the worst performer on the list, down by 91% year-to-date (YTD). To continue reading this as well as other DeFi and Web3 news, visit us at thedefiant.io